Zhu, Y., Ackers-Johnson, M., Shanmugam, M.K., Pakkiri, L.S., Drum, C.L., Chen, Y., Kim, J., Paltzer, W.G., Mahmoud, A.I., Wen Tan, W.L., Lee, M.C.J., Jiang, J., Luu, D.A.T., Ng, S.L., Li, P.Y.Q., Wang, A., Qi, R., Ong, G.J.X., Ng Yu, T., Haigh, J.J., Tiang, Z., Richards, A.M., Foo, R. Asparagine synthetase marks a distinct dependency threshold for cardiomyocyte dedifferentiation. Circulation. 2024 Apr 8. PMID: 38586957.

Paltzer, W.G., Aballo, T.J., Bae, J., Flynn, C.G.K., Wanless, K.N., Hubert, K.A., Nuttall, D.J., Perry, C., Nahlawi, R., Ge, Y., Mahmoud, A.I.*. mTORC1 Regulates the Metabolic Switch of Postnatal Cardiomyocytes During Regeneration. Journal of Molecular and Cellular Cardiology, 2024 Feb;187:15-25. (*corresponding author).


Aballo, T.J., Bae, J., Paltzer, W.G., Chapman, E.A., Salamon, R.J., Mann, M.M., Ge, Y.*, Mahmoud, A.I.*. Integrated Proteomics Identifies Troponin I Isoform Switch as a Regulator of a Sarcomere-Metabolism Axis During Cardiac Regeneration. bioRxiv, 2023 Oct 23. (*co-corresponding authors).

Mahmoud, A.I.*. Metabolic switches during development and regeneration. Development, 2023 Oct 15;150(20):dev202008. (*corresponding author)

Salamon, R.J., Halbe, P., Kasberg, W., Bae, J., Audhya, A., Mahmoud, A.I.*. Parasympathetic and sympathetic axons are bundled in the cardiac ventricles and undergo physiological reinnervation during heart regeneration. iScience, 2023 Aug 25;26(10):107709. (*corresponding author).

Salamon, R.J., McKeon, M.C., Bae, J., Zhang, X., Paltzer, W.G., Wanless, K.N., Schuett, A.R., Nuttall, D.J., Nemr, S.A., Sridharan, R., Lee, Y., Kamp, T.J., Mahmoud, A.I.*. LRRC10 regulates mammalian cardiomyocyte cell cycle during heart regeneration. NPJ Regenerative Medicine, 2023 Jul 28;8(1):39. (*corresponding author).

Aballo, T.J., Roberts, D.S., Bayne, E.F., Zhu, W., Walcott, G., Mahmoud, A.I., Zhang, J., Ge, Y. Integrated proteomics reveals alterations in sarcomere composition and developmental processes during postnatal swine heart development. Journal of Molecular and Cellular Cardiology, 2023 Mar; 176:33-40.


Brandt E.B., Mahmoud A.I.* (2022) Quantifying CardiomyocyteProliferation and Nucleation to Assess Mammalian Cardiac Regeneration. Methods in Molecular Biology, 2022;2485:243-253. (*corresponding author).

Salamon, R.J., Mahmoud, A.I.*. Bridging the communication gap: cardiomyocytes reciprocate sympathetic nerve signalling. Journal of Physiology, 2022 May 25. (*corresponding author).


Bae, J., Paltzer, W.G., Mahmoud, A.I.*. The role of metabolism in heart failure and regeneration. Frontiers in Cardiovascular Medicine, 2021 Jul 16;8:702920. (*corresponding author).

Tampakakis, E.*, Mahmoud, A.I.*. The role of hormones and neurons in cardiomyocyte maturation. Seminars in Cell & Developmental Biology, 2021 Oct;118:136-143. (*co-corresponding authors).

Bae, J., Salamon, R.J., Brandt, E.B., Paltzer, W.G., Zhang, Z., Britt, E.C., Hacker, T.A., Fan, J., Mahmoud, A.I.*. Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration. Circulation, 2021 May 18;143(20):1973-1986. (*corresponding author)


Salamon, R.J., Zhang, Z., Mahmoud, A.I.*. Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging. Journal of Visualized Experiments, 2020 Mar 17; (157). (*corresponding author).


Brandt, E.B.,Bashar, S.J., Mahmoud, A.I.*. Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy. Bioelectronic Medicine, 2019 Jun 26; 5:8. (*corresponding author).


Mahmoud, A.I.*and Porrello, E.R*. Upsizing Neonatal Heart Regeneration. Circulation, 2018 Dec 11;138(24):2817-2819. (*co-corresponding authors).

Mahmoud, A.I., Galdos, F.X., Dinan, K.A., Jedrychowski, M.P., Davis, J.C., Vujic, A., Rachmin, I., Shigley, C., Pancoast, J.R., Lee, S., Hollister-Lock, J., MacGillivray, C.M., Gygi, S.P., Melton, D.A., Weir, G.C., Lee, R.T. Apolipoprotein E is a Pancreatic Extracellular Factor That Maintains Mature β-Cell Gene Expression. PLOS ONE, 2018 Oct 10;13(10):e0204595.


Vujic, A., Mahmoud, A.I., Lee, R.T. A breakdown in cooperativity leads to cardiac identity crisis. Cell (2016) Dec 15;167(7):1674-1676. doi: 10.1016/j.cell.2016.11.056.

Mahmoud, A.I., Lee, R.T. Adrenergic function restoration in the transplanted heart: A role for neural crest-derived cells. Cardiovasc Res (2016) Mar 1;109(3):348-9. doi: 10.1093/cvr/cvw013.


Mahmoud, A.I.*, O’Meara, C.C.*, Gemberling, M., Zhao, L., Bryant, D.M., Zheng, R., Gannon, J.B., Cai, L., Choi, W., Egnaczyk, G.F., Burns, C.E., Burns, C.G., MacRae, C.A., Poss, K.D., Lee, R.T. Nerves regulate cardiomyocyte proliferation and heart regeneration. Dev Cell 2015 Aug 24;34(4):387-99. doi: 10.1016/j.devcel.2015.06.017. (* equal contribution)


Puente, B.N., Kimura, W., Muralidhar, S.A., Moon, J., Amatruda, J.F., Phelps, K.L., Grinsfelder, D., Rothermel, B.A., Chen, R., Garcia, J.A., Santos, C.X., Thet, S., Mori, E., Kinter, M.T., Rindler, P.M., Zacchigna, S., Mukherjee, S., Chen, D.J., Mahmoud, A.I., Giacca, M., Rabinovitch, P.S., Aroumougame, A., Shah, A.M., Szweda, L.I., Sadek, H.A. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell (2014) Apr 24;157(3):565-79. doi: 10.1016/j.cell.2014.03.032.

Mahmoud, A.I.*, Canseco, D.*, Xiao, F., Sadek, H.A. Cardiomyocyte cell cycle: Meis-ing something? Cell Cycle (2014);13(7):1057-8. doi: 10.4161/cc.28379. (* equal contribution)

Aurora, A.B., Porrello, E.R., Tan, W., Mahmoud, A.I., Hill, J.A., Bassel-Duby, R., Sadek, H.A., Olson, E.N. Macrophages are required for neonatal heart regeneration. J Clin Invest (2014) Mar;124(3):1382-92. doi: 10.1172/JCI72181.

Mahmoud, A.I., Porrello, E.R., Kimura, W., Olson, E.N., Sadek, H.A. Surgical models for cardiac regeneration in neonatal mice. Nat Protoc (2014) Feb;9(2):305-11. doi: 10.1038/nprot.2014.021.


Muralidhar, S.A.*, Mahmoud, A.I.*, Canseco, D., Xiao, F., Sadek, H.A. Harnessing the power of dividing cardiomyocytes. Glob Cardiol Sci Pract (2013) Nov 1;2013(3):212-21. doi: 10.5339/gcsp.2013.29. (* equal contribution)

Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) Aug 20;110(34):13839-44. doi: 10.1073/pnas.1313192110.

Mahmoud, A.I.*, Kocabas, F.*, Muralidhar, S.A.*, Kimura, W., Koura, A.S., Thet, S., Porrello, E.R., Sadek, H.A. Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature (2013) May 9;497(7448):249-253. doi: 10.1038/nature12054. (* equal contribution)

Porrello, E.R.*, Mahmoud, A.I.*, Simpson, E., Johnson, B.A., Grinsfelder, D., Canseco, D., Mammen, P.P, Rothermel, B.A., Olson, E.N., Sadek, H.A. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci U S A (2013) Jan 2;110(1):187-92. doi: 10.1073/pnas.1208863110. (* equal contribution)


Mahmoud, A.I. and Porrello, E.R. Turning back the cardiac regenerative clock: lessons from the neonate. Trends Cardiovasc Med (2012) Jul;22(5):128-33. doi: 10.1016/j.tcm.2012.07.008.

Kocabas, F., Mahmoud, A.I., Porrello, E.R., Sosic, D., Olson, E.N., DeBerardinis, R.J., Sadek, H.A. The hypoxic epicardial and subepicardial microenvironment. J Cardiovasc Transl Res (2012) Oct;5(5):654-65.

Aurora, A.B., Mahmoud, A.I., Luo, X., Johnson, B.A., van Rooij, E., Matsuzaki, S., Humphries, K.M., Hill, J.A., Bassel-Duby, R., Sadek, H.A., Olson, E.N. MicroRNA-214 protects the heart from ischemic injury by controlling Ca2+ overload and cell death. J Clin Invest (2012) Apr;122(4):1222-32. doi: 10.1172/JCI59327.


Porrello, E.R., Mahmoud, A.I., Simpson, E., Hill, J.A., Richardson, J.A., Olson, E.N., Sadek, H.A. Transient regenerative potential of the neonatal mouse heart. Science (2011) Feb 25;331(6020):1078-80. doi: 10.1126/science.1200708.


Simsek, T., Kocabas, F., Zheng, J, DeBerardinis, R.J., Mahmoud, A.I., Olson, E.N., Schneider, J.W., Zhang, C.C., Sadek, H.A. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell (2010) Sep 3;7(3):380-90. doi: 10.1016/j.stem.2010.07.011.

Book Chapters


Mahmoud, A.I., Lee, R.T. Past and Future of Cell Based Heart Repair. In: Cardiac Regeneration (Ieda, M., Zimmermann, W.H., editors) Springer (2017).