Aballo, T.J., Roberts, D.S., Bayne, E.F., Zhu, W., Walcott, G., Mahmoud, A.I., Zhang, J., Ge, Y. Integrated proteomics reveals alterations in sarcomere composition and developmental processes during postnatal swine heart development. Journal of Molecular and Cellular Cardiology, 2023 Mar; 176:33-40.

Salamon, R.J., Halbe, P., Kasberg, W., Bae, J., Audhya, A., Mahmoud, A.I.*. Defining cardiac nerve architecture during development, disease, and regeneration. bioRxiv, doi: 10.1101/2022.12.31.522405


Brandt E.B., Mahmoud A.I. (2022) Quantifying CardiomyocyteProliferation and Nucleation to Assess Mammalian Cardiac Regeneration. In: Coulombe K.L., Black III L.D. (eds) Cardiac Tissue Engineering. Methods in Molecular Biology, vol 2485.

Salamon, R.J., Mahmoud, A.I.*. Bridging the communication gap: cardiomyocytes reciprocate sympathetic nerve signalling. Journal of Physiology, 2022 May 25.


Bae, J., Paltzer, W.G., Mahmoud, A.I.*. The role of metabolism in heart failure and regeneration. Frontiers in Cardiovascular Medicine, 2021 Jul 16;8:702920. (*corresponding author).

Tampakakis, E.*, Mahmoud, A.I.*. The role of hormones and neurons in cardiomyocyte maturation. Seminars in Cell & Developmental Biology, 2021 Oct;118:136-143. (*co-corresponding authors).

Bae, J., Salamon, R.J., Brandt, E.B., Paltzer, W.G., Zhang, Z., Britt, E.C., Hacker, T.A., Fan, J., Mahmoud, A.I.*. Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration. Circulation, May 18;143(20):1973-1986. (*corresponding author)


Salamon, R.J., Zhang, Z., Mahmoud, A.I.*. Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging. Journal of Visualized Experiments, 2020 Mar 17; (157). (*corresponding author).


Brandt, E.B.,Bashar, S.J., Mahmoud, A.I.*. Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy. Bioelectronic Medicine, 2019 Jun 26; 5:8. (*corresponding author).


Mahmoud, A.I.*and Porrello, E.R*. Upsizing Neonatal Heart Regeneration. Circulation, 2018 Dec 11;138(24):2817-2819. (*co-corresponding authors).

Mahmoud, A.I., Galdos, F.X., Dinan, K.A., Jedrychowski, M.P., Davis, J.C., Vujic, A., Rachmin, I., Shigley, C., Pancoast, J.R., Lee, S., Hollister-Lock, J., MacGillivray, C.M., Gygi, S.P., Melton, D.A., Weir, G.C., Lee, R.T. Apolipoprotein E is a Pancreatic Extracellular Factor That Maintains Mature β-Cell Gene Expression. PLOS ONE, 2018 Oct 10;13(10):e0204595.


Vujic, A., Mahmoud, A.I., Lee, R.T. A breakdown in cooperativity leads to cardiac identity crisis. Cell (2016) Dec 15;167(7):1674-1676. doi: 10.1016/j.cell.2016.11.056.

Mahmoud, A.I., Lee, R.T. Adrenergic function restoration in the transplanted heart: A role for neural crest-derived cells. Cardiovasc Res (2016) Mar 1;109(3):348-9. doi: 10.1093/cvr/cvw013.


Mahmoud, A.I.*, O’Meara, C.C.*, Gemberling, M., Zhao, L., Bryant, D.M., Zheng, R., Gannon, J.B., Cai, L., Choi, W., Egnaczyk, G.F., Burns, C.E., Burns, C.G., MacRae, C.A., Poss, K.D., Lee, R.T. Nerves regulate cardiomyocyte proliferation and heart regeneration. Dev Cell 2015 Aug 24;34(4):387-99. doi: 10.1016/j.devcel.2015.06.017. (* equal contributions)


Puente, B.N., Kimura, W., Muralidhar, S.A., Moon, J., Amatruda, J.F., Phelps, K.L., Grinsfelder, D., Rothermel, B.A., Chen, R., Garcia, J.A., Santos, C.X., Thet, S., Mori, E., Kinter, M.T., Rindler, P.M., Zacchigna, S., Mukherjee, S., Chen, D.J., Mahmoud, A.I., Giacca, M., Rabinovitch, P.S., Aroumougame, A., Shah, A.M., Szweda, L.I., Sadek, H.A. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell (2014) Apr 24;157(3):565-79. doi: 10.1016/j.cell.2014.03.032.

Mahmoud, A.I.*, Canseco, D.*, Xiao, F., Sadek, H.A. Cardiomyocyte cell cycle: Meis-ing something? Cell Cycle (2014);13(7):1057-8. doi: 10.4161/cc.28379. (* equal contributions)

Aurora, A.B., Porrello, E.R., Tan, W., Mahmoud, A.I., Hill, J.A., Bassel-Duby, R., Sadek, H.A., Olson, E.N. Macrophages are required for neonatal heart regeneration. J Clin Invest (2014) Mar;124(3):1382-92. doi: 10.1172/JCI72181.

Mahmoud, A.I., Porrello, E.R., Kimura, W., Olson, E.N., Sadek, H.A. Surgical models for cardiac regeneration in neonatal mice. Nat Protoc (2014) Feb;9(2):305-11. doi: 10.1038/nprot.2014.021.


Muralidhar, S.A.*, Mahmoud, A.I.*, Canseco, D., Xiao, F., Sadek, H.A. Harnessing the power of dividing cardiomyocytes. Glob Cardiol Sci Pract (2013) Nov 1;2013(3):212-21. doi: 10.5339/gcsp.2013.29. (* equal contributions)

Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci U S A (2013) Aug 20;110(34):13839-44. doi: 10.1073/pnas.1313192110.

Mahmoud, A.I.*, Kocabas, F.*, Muralidhar, S.A.*, Kimura, W., Koura, A.S., Thet, S., Porrello, E.R., Sadek, H.A. Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature (2013) May 9;497(7448):249-253. doi: 10.1038/nature12054. (* equal contributions)

Porrello, E.R.*, Mahmoud, A.I.*, Simpson, E., Johnson, B.A., Grinsfelder, D., Canseco, D., Mammen, P.P, Rothermel, B.A., Olson, E.N., Sadek, H.A. Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family. Proc Natl Acad Sci U S A (2013) Jan 2;110(1):187-92. doi: 10.1073/pnas.1208863110. (* equal contributions)


Mahmoud, A.I. and Porrello, E.R. Turning back the cardiac regenerative clock: lessons from the neonate. Trends Cardiovasc Med (2012) Jul;22(5):128-33. doi: 10.1016/j.tcm.2012.07.008.

Kocabas, F., Mahmoud, A.I., Porrello, E.R., Sosic, D., Olson, E.N., DeBerardinis, R.J., Sadek, H.A. The hypoxic epicardial and subepicardial microenvironment. J Cardiovasc Transl Res (2012) Oct;5(5):654-65.

Aurora, A.B., Mahmoud, A.I., Luo, X., Johnson, B.A., van Rooij, E., Matsuzaki, S., Humphries, K.M., Hill, J.A., Bassel-Duby, R., Sadek, H.A., Olson, E.N. MicroRNA-214 protects the heart from ischemic injury by controlling Ca2+ overload and cell death. J Clin Invest (2012) Apr;122(4):1222-32. doi: 10.1172/JCI59327.


Porrello, E.R., Mahmoud, A.I., Simpson, E., Hill, J.A., Richardson, J.A., Olson, E.N., Sadek, H.A. Transient regenerative potential of the neonatal mouse heart. Science (2011) Feb 25;331(6020):1078-80. doi: 10.1126/science.1200708.


Simsek, T., Kocabas, F., Zheng, J, DeBerardinis, R.J., Mahmoud, A.I., Olson, E.N., Schneider, J.W., Zhang, C.C., Sadek, H.A. The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell (2010) Sep 3;7(3):380-90. doi: 10.1016/j.stem.2010.07.011.

Book Chapters


Mahmoud, A.I., Lee, R.T. Past and Future of Cell Based Heart Repair. In: Cardiac Regeneration (Ieda, M., Zimmermann, W.H., editors) Springer (2017).